Sign in →

Test Code 8AINH Factor VIII Inhibitor Profile, Professional Interpretation


Specimen Required


 


Secondary ID

607442

Useful For

Interpretation for the detection of the presence and titer of a specific factor inhibitor directed against coagulation factor VIII

Disease States

  • Hemophilia A

Method Name

Only orderable as a reflex. For more information see 8INHE / Factor VIII Inhibitor Evaluation, Plasma.

 

Medical Interpretation

Reporting Name

FVIII Inhib Profile Prof Interp

Specimen Type

Plasma Na Cit

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Clinical Information

Factor VIII (FVIII) inhibitors are IgG antibodies directed against coagulation FVIII that typically result in development of potentially life-threatening hemorrhage. These antibodies may develop in 1 of 4 different patient populations:

-Patients with congenital FVIII deficiency (hemophilia A) in response to therapeutic infusions of factor VIII concentrate

-Older nonhemophiliac adult patients (not previously factor VIII deficient)

-Women in postpartum period

-Patients with other autoimmune illnesses

Reference Values

Only orderable as a reflex. For more information see 8INHE / Factor VIII Inhibitor Evaluation, Plasma.

 

An interpretive report will be provided.

Interpretation

When no significant abnormalities are detected, a simple descriptive interpretation is provided. When abnormal results are detected, a detailed interpretation is given, including an overview of the results and of their significance, a correlation to available clinical information, and elements of differential diagnosis.

Cautions

No significant cautionary statements

Clinical Reference

1. Kasper CK. Treatment of factor VIII inhibitors. Prog Hemost Thromb. 1989;9:57-86

2. Peerschke EI, Castellone DD, Ledford-Kraemer M, et al. Laboratory assessment of FVIII inhibitor titer. Am J Clin Pathol. 2009;131(4):552-558

3. Pruthi RK, Nichols WL. Autoimmune factor VIII inhibitors. Curr Opin Hematol. 1999;6(5):314-322

4. Kottke-Marchant K, ed. Laboratory Hematology Practice. Wiley Blackwell Publishing; 2012

5. Hoffman R, Benz Jr EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Elsevier; 2018

Method Description

A coagulation expert (clinician or hematopathologist) reviews the laboratory data, and an interpretive report is issued.

Day(s) Performed

Monday through Friday

Report Available

3 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

Not Applicable

CPT Code Information

85390-26

LOINC Code Information

Test ID Test Order Name Order LOINC Value
8AINH FVIII Inhib Profile Prof Interp 69049-5

 

Result ID Test Result Name Result LOINC Value
607486 Reviewed by 18771-6
607442 FVIII Inhib Profile Prof Interp 69049-5