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HelpTest Code FBCFS Barbiturates Confirmation, Serum
Specimen Required
Only orderable as a reflex. For more information see:
FDA1S / Drugs of Abuse (10 panel) and Alcohol Screen, Serum
FD10S / Drugs of Abuse Screen, Serum
Secondary ID
75839Method Name
Only orderable as a reflex. For more information see:
FDA1S / Drugs of Abuse (10 panel) and Alcohol Screen, Serum
FD10S / Drugs of Abuse Screen, Serum
Gas Chromatography/Mass Spectrometry (GC/MS)
Reporting Name
Barbiturates Confirmation, SSpecimen Type
Serum RedSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 14 days |
| Frozen | 30 days |
Reference Values
Only orderable as a reflex. For more information see:
FDA1S / Drugs of Abuse (10 panel) and Alcohol Screen, Serum
FD10S / Drugs of Abuse Screen, Serum
Reporting limit determined each analysis.
Butabarbital: None detected
Butalbital: None detected
Pentobarbital: None detected
Secobarbital: None detected
Phenobarbital: None detected
Performing Laboratory
NMS LabsCPT Code Information
80345
G0480 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FBCFS | Barbiturates Confirmation, S | Not Provided |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| Z5287 | Butabarbital | 18384-8 |
| Z5288 | Butalbital | 82971-3 |
| Z5290 | Pentobarbital | 82969-7 |
| Z5291 | Secobarbital | 82968-9 |
| Z5292 | Phenobarbital | 60468-6 |
Reject Due To
All specimens will be evaluated by the processing and performing laboratories for test suitabilityClinical Information
Interpretation
Butabarbital:
Plasma concentrations of 2-3 mcg/mL produce sedation and plasma concentrations of 25 mcg/mL produce sleep in most patients. Plasma concentrations of greater than 30 mcg/mL may produce coma and plasma concentrations in excess of 50 mcg/mL are potentially lethal.
Butalbital:
A single oral 100 mcg dose resulted in a mean peak blood concentration of 2.1 mcg/mL (range: 1.7-2.6 mcg/mL) at 2 hours, with a decline to 1.5 mcg/mL (range: 1.3-1.7 mcg/mL) by 24 hours. Potentially toxic at plasma concentrations greater than 10 mcg/mL.
Pentobarbital:
Peak serum concentrations of 1.2-3.1 mcg/mL were produced 0.5-2.0 hours after a 100 mg oral dose and peak serum concentration of 3 mcg/mL were produced 6 min. following a 100 mg IV dose. Potentially toxic at blood concentrations greater than 10 mcg/mL.
Secobarbital:
A 3.3 mg/kg oral dose (approximately 230 mg/70 kg) produced a mean peak blood concentration of 2.0 mcg/mL (range, 1.8-2.2 mcg/mL) at 3 hours, diminishing to 1.3 mcg/mL by 20 hours and 0.8 mcg/mL by 40 hours. Potentially toxic at blood concentrations greater than 8 mcg/mL.
Phenobarbital:
Recommended serum concentration range during anticonvulsant therapy with primidone: 10-40 mcg/mL.