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Test Code FIGA Anti-IgA


Specimen Required


Specimen Type: Serum

Container/Tube: Red or SST

Specimen Volume: 1 mL

 

Collection Instructions: Draw blood in a plain, red-top tube(s) or serum gel tube(s). Spin down and send 1 mL of serum refrigerate in a plastic vial.


Secondary ID

57552

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Anti-IgA

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  30 days
  Ambient  7 days

Reject Due To

Hemolysis: NA
Thawing: Warm OK; Cold OK
Lipemia: NA
Icterus: NA
Other: NA

Clinical Information

For the evaluation of patients with recurrent infection for the possibility of IgA deficiency (IgAD). Patients with IgA deficiency may develop antibodies against IgA that make them susceptible to adverse reactions to blood products including intravenous immunoglobulin.

 

Reference Values

<99 U/mL

 

Patients with IgG antibodies against IgA may suffer from anaphylactoid reactions when given IVIG that contains small quantities of IgA. In one study (Clinical Immunology 2007; 122:156) five out of eight patients with IgG anti-IgA antibodies developed anaphylactoid reactions when IVIG was administered.

 

Clinical Reference

Hammarstrom L, Vorechovsky I, Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol. 2000; 120:225-231.

- Burrows D, Cooper MD: IgA Deficiency. Adv Immunol 1997; 65:245-276.

- Aghamohammadi A, Mohammadi J, Parvaneh N, Rezael N, Moin M, Espanol T. and Hammarstrom L. Progression of Selective IgA

Deficiency to Common Variable Immunodeficiency. Int Arch Allergy Immunol 2008;147:87-92.

Horn J, Thon V, Bartonkova D, Salzer U, warnatz K, Schlesier M, Peter H, and Grimbacher B. Anti-IgA antibodies in Common

Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy. Clin Immunol 2007;122:156-162.

Method Description

ELISA using human polyclonal IgA coupled to the solid phase.

Day(s) Performed

Thursday

Report Available

5 to 16 days

Performing Laboratory

Eurofins Viracor

Test Classification

This test was developed and its performance characteristics determined by Viracor Eurofins. It has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83520

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FIGA Anti-IgA 13312-4

 

Result ID Test Result Name Result LOINC Value
FIGA Anti-IgA 13312-4