Test Code SOFT: Z0591 Conventional Smear-Screen, Varies
Additional Codes
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Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Requirements
Patient Preparation: For optimal interpretation, Papanicolaou smears should be collected near the middle of the menstrual cycle. No douching, lubricant use, or sexual intercourse for 24 hours prior to specimen collection.
Container/Tube: Slide
Specimen Volume: Circular scrape of cervical os
Collection Instructions:
1. Specimen containers must be labeled with a minimum of 2 unique identifiers (patient's name, and medical record number or date of birth). Containers should also be labeled with specimen source, and date collected.
2. Glass slides may be labeled with a single unique identifier, but 2 identifiers are preferred. If multiple slides are submitted, each slide must have proper identification. Glass slides should be identified with the patient's name and a second patient identifier that is also on the accompanying paperwork (ie, medical record number or date of birth)
3. Fix slides immediately in 95% alcohol or treat with commercially available spray fixative.
Specimen Transport Temperature
Specimen |
Temperature |
Time |
Special Container |
Varies |
Ambient (preferred) |
|
SLIDE |
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Refrigerated |
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SLIDE |
Reference Values
Satisfactory for evaluation. Negative for intraepithelial lesion or malignancy.
Day(s) Test Set Up
Monday through Friday
Test Classification and CPT Coding
P3000
88164
88141-CVSPC (if appropriate)
Methodology
Light Microscopy
Method Description
Papanicolaou-stained slides are microscopically examined by a cytotechnologist. Abnormal findings are reviewed and reported by a pathologist (charged separately).(Unpublished Mayo method)
Clinical Information
Squamous cell carcinoma of the cervix is believed to develop in progressive stages from normal through precancerous (dysplastic, intraepithelial neoplastic, stages II in situ carcinoma, and eventually invasive carcinoma). This sequence is felt to develop over a matter of years in most patients.
The etiology of cervical carcinoma is unknown but the disease is believed to be related to sexual activity and possibly sexually transmitted viral infections such as human papilloma virus.
Most cervical carcinomas and precancerous conditions occur in the transformation zone (squamo-columnar junction), therefore, this area needs to be sampled if optimum results are to be obtained.
Useful For
Screening for cervical carcinoma and a number of infections of the female genital tract including human papillomavirus, herpes, Candida, and Trichomonas