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Test Code SOFT: Z1000 Drug Screen, Prescription/Over the Counter, Serum

Additional Codes

Ordering Mnemonic Mayo Test ID
EPIC NAME: MISC. LAB TEST DSS

 EPIC CODWE: LAB000

Reporting Name

Drug Screen, Prescription/OTC, S

Useful For

Detection and identification of prescription or over the counter drugs frequently found in drug overdose or used with a suicidal intent

 

Qualitatively identifying drugs present in the specimen; quantification of identified drugs, when available, may be performed upon client request

 

This test is not intended for therapeutic drug monitoring or compliance testing.

 

This test is not intended for use in employment-related testing.

 

This test is not useful for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, amphetamine type stimulants.

Method Name

Gas Chromatography Mass Spectrometry (GC-MS)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum Red


Ordering Guidance


This test is not performed using chain of custody. For chain-of-custody testing, order DSSX / Drug Screen, Prescription/Over the Counter, Chain of Custody, Serum.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST tubes are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 2.75 mL

Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

1.1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  3 hours

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

Drugs detected are presumptive. Additional testing may be required to confirm the presence of any drugs detected.

Day(s) Performed

Monday through Sunday

CPT Code Information

80307

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DSS Drug Screen, Prescription/OTC, S 20785-2

 

Result ID Test Result Name Result LOINC Value
31072 Drugs detected: 20785-2
31168 Chain of Custody 77202-0

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Clinical Information

This test looks for a broad spectrum of prescription and over-the-counter drugs. It is designed to detect drugs that have toxic effects, as well as known antidotes or active therapies that a clinician can initiate to treat the toxic effect. The test is intended to help physicians manage an apparent overdose or intoxicated patient, or to determine if a specific set of symptoms might be due to the presence of drugs. This test is not appropriate for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, and amphetamine type stimulants.

 

Drugs of toxic significance that are not detected by this test are digoxin, lithium, and many drugs of abuse or illicit drugs, some benzodiazepines, and some opioids.

 

For detection limits for drugs detected in this test see Prescription and Over-the-Counter Drug Screening List and Limits of Detection.

Interpretation

The drugs that are detected by this test are listed in Prescription and Over-the-Counter Drug Screening List and Limits of Detection.

 

The pharmacology of each drug determines how the test should be interpreted. A detailed discussion of each drug is beyond the scope of this text. If a clinical interpretation is required, contact Mayo Clinic Laboratories at 800-533-1710 and ask to speak to a toxicology consultant.

 

Each report will indicate the drugs detected.

Cautions

Specimens collected in serum gel tubes are not acceptable, as the drug/analyte can absorb on the gel and lead to falsely decreased concentrations.

Clinical Reference

1. Langman LJ, Bechtel LK, Holstege CP. Clinical toxicology. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:chap 43

2. Baselt RC. Disposition of Toxic Drugs and Chemical in Man. 12th ed. Biomedical Publications; 2020

Method Description

Screening is by gas chromatography mass spectroscopy.(Unpublished Mayo method)

Report Available

3 days

Specimen Retention Time

2 weeks

Secondary ID

8421

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.